E-ISSN: 2149-6048 ISSN: 2149-5807
Role of Cardiac Biomarkers and Tomographic Right Ventricular Dysfunction Findings in the Treatment of Pulmonary Thromboembolism
PDF
Cite
Share
Request
Original Article
VOLUME: ISSUE:
P: -

Role of Cardiac Biomarkers and Tomographic Right Ventricular Dysfunction Findings in the Treatment of Pulmonary Thromboembolism

DOI: 10.4274/eajem.galenos.2024.59320
Maşide Arı 1
Zeycan Kübra Cevval 2
Eren Usul 3
Emrah Arı 4
Uğur Kahveci 5
1. Atatürk Sanatorium Training and Research Hospital, Clinic of Pulmonology, Ankara, Turkey
2. Kastamonu Training and Research Hospital, Clinic of Radiology, Kastamonu, Turkey
3. Etlik City Hospital, Clinic of Emergency Medicine, Ankara, Turkey
4. Mamak Public Hospital, Clinic of Emergency Medicine, Ankara, Turkey
5. Eskişehir City Hospital, Clinic of Emergency Medicine, Eskişehir, Turkey
No information available.
No information available
Received Date: 26.05.2024
Accepted Date: 18.09.2024
Online Date: 22.10.2024
PDF
Cite
Share
Request

Abstract

Aim: Deaths from acute pulmonary thromboembolism are caused by right ventricular dysfunction (RVD) and often occur within the first hour. Diagnostic computed tomography-pulmonary angiography (CTPA) is a useful tool for the early and rapid evaluation of RVD. We aimed to evaluate the effect of RVD findings on risk classification and treatment.

Materials and Methods: This retrospective study included patients who applied to the emergency department on specified dates and were diagnosed with pulmonary thromboembolism. The right ventricle (RV) and left ventricle (LV) diameters (mm), ratio of these diameters RV/LV, pulmonary artery and aortic diameter (mm), troponin, and BNP were evaluated.

Results: A total of 119 patients were studied. The average age of the participants was 63.3 years. The mortality rate was 12.6%. Reperfusion therapy was applied to 25 (21%) patients. RV/LV was superior for predicting thrombolytic therapy. N-terminal proBNP (NT-proBNP) was more significant than troponin. When both parameters were evaluated together, the result was superior in predicting reperfusion therapy in patients with RVD.

Conclusion: CTPA can be used safely to determine the risk group and for treatment with its high sensitivity. NT-proBNP is an important biomarker for determining thrombolytic treatment, and its diagnostic specificity increases when evaluated together with RV/LV.