ABSTRACT

We aimed to evaluate the effects of genetic polymorphisms on the frequency of application to the emergency service and on the complications with use of warfarin in this study.

Seventy patients were included in the study. Two groups were composed: one group of 40 patients who used warfarin and with international normalized ratios (INRs) ≥3.5 IU and a second group of 30 control group patients with normal INR levels. Blood samples were examined through the warfarin dosage sensitivity test.

VKORC 1 heterozygote type AG was the most frequently seen allele in 17 of the haplotype patients (42.5%), in 12 of the control group patients (40%), in 21 of the CYP2C9 *1/*1 patients (52.5%), and in 17 of the CYP2C9 *1/*1 control group patients. No statistically significant difference was identified between the groups (p>0.05). No statistically significant relationship was established as regards the frequency of emergency service visits and bleeding complications with CYP2C9 and VKORC 1 genes.

The most common haplotypes VKORC 1 heterozygote type AG and CYP2C9 *1/*1. No relationship was identified between INR levels and VKORC 1 and CYP2C9 haplotypes. These genes have no effect on bleeding and frequent applications of emergency service.

Keywords: Warfarin, gene polymorphism, emergency service, VKORC 1, CYP2C9