ABSTRACT

Many epidemyologic studies have been committed related with early diagnosis of acute myocardial infarction and coronary heart disease (CHD). The objective of this study is to determine the importances of CRP, malondialdehyde and genetic variations of factor V Leiden and prothrombin 20210 G/A in acute myocardial infarction.

In this preliminary controlled experiment, risk factors,CRP levels,malondialdehyde levels,factor V Leiden and prothrombin 20210 G/A genetic variations of 27 patients brought to our emergency department with chest pain, diagnosed acute myocardial infarction and interned in coronary intensive care unit were determined. Statistical analysis was made using Chisquare, Student-t, Mann-Whitney U and Wilcoxon W tests.

81.5% of our study sample comprised of male patients having one or more risk factors of coronary heart disease. We fixed the CRP levels meaningfully high (14±21 mg/dL p<0.05 among male patients and 40±42 mg/dL, p<0.05 among female patients) among patients of acute myocardial infarction. During a period of 12 hours after the infarction we fixed that the malondialdehyde levels were meaningfully high (5.9±1.5 nmol/mL, p<0.05). We determined a heterozygote prothrombin 20210 G/A genetic variation in one (3.7%) patient and factor V Leiden in another one (3.7%) patient and we determined no statistical difference in terms of factor variations according to control group (p>0.05).

High level of CRP after acute myocardial infarction should be assessed as an independent risk factor for CHD. High level malondialdehyde is an implication of reperfusion injury. Genetic variations might only be significant through presence of major risk factors for CHD.

Keywords: AMI, CRP, Malondialdehyde, FVL, Prothrombin20210G/A