E-ISSN: 2149-6048 ISSN: 2149-5807
THE EFFECTS OF ERDOSTEINE ON THE LEVELS OF GLUTATHIONE, SERUM TNF-ℑ, RENAL AND LIVER TISSUE MDA IN A SEPSIS MODEL
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Original Article
VOLUME: 6 ISSUE: 1
P: 19-23
March 2007

THE EFFECTS OF ERDOSTEINE ON THE LEVELS OF GLUTATHIONE, SERUM TNF-ℑ, RENAL AND LIVER TISSUE MDA IN A SEPSIS MODEL

Eurasian J Emerg Med 2007;6(1):19-23
M. Gül 1
M. Ayan 1
A. Seydanoğlu 1
B. Cander 1
S. Girişgin 1
İ. Erayman 2
1. Selçuk Üniversitesi Meram Tıp Fakültesi Acil Tıp Anabilim Dalı
2. Selçuk Üniversitesi Meram Tıp Fakültesi İnfeksiyon Hastalıkları Anabilim Dalı
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ABSTRACT

Aim:

To investigate the effect of erdosteine, an antioxidant agent, on free oxygen radicals and their plasma values in an animal model of sepsis.

Methods:

30 Sprague-Dawley rats, weighing between 180 and 200 grams were divided into 3 groups. Group I (Sham), Group II (Sepsis), and Group III (Sepsis + Erdosteine 20 mg/kg/day). Sepsis was created by caecum ligation and perforation. Erdosteine was administered at 0 and 12 hours. Blood samples were drawn at 24 hours and erythrocyte glutathion (GSH) and serum tumor necrosis factor alpha (TNF-α) were measured. After the animals were sacrificed, histopathological examination and measurement of tissue malondialdehyde (MDA) was performed on lung, liver, and kidney tissue samples.

Results:

TNF-α and erythrocyte GSH values were not significantly different between groups (p>0.05). Kidney and liver MDA levels did not statistically differ between groups (p>0.05). Histopathological examination of lung, liver, and kidney tissues found no difference between groups (p>0.05).

Conclusion:

Erdosteine was ineffective in this experimental sepsis model. Further studies are required to determine the possible useful effects of erdosteine.

Keywords:
Sepsis, Erdosteine, Glutathion, TNF- α, MDA