Original Article

The Relationship Between Acute Ischemic Stroke and Acute Phase Reactants


  • Mehmet Gül
  • Başar Cander
  • Sadık Girişgin
  • Serhat Tokgöz
  • Sedat Koçak
  • Metin Bircan
  • Halil Kaya

Received Date: 04.04.2011 Accepted Date: 11.05.2011 Eurasian J Emerg Med 2011;10(4):161-164


The role played by inflammation in the etiopathogenesis of stroke has been intensively investigated in recent years. In this clinical study, the relationship between acute phase reactants (APR) and acute ischemic stroke (AIS) was investigated.

Material and Methods:

126 patients with AIS and 104 volunteer individuals as controls were included in the study. White blood count (WBC), C-reactive protein (CRP), fibrinogen, lipoprotein (a) (Lp a) and complementary fragments (C3 and C4) levels were investigated both in patients with AIS and the controls.


In patients with AIS, WBC and fibrinogen values were significantly higher than the controls (p<0.001, p<0.001, p<0.001, respectively). There was no significant difference between Lp(a), C3 and C4 values in patients with AIS and controls (p=0.727, p=0.163, p=0.497, respectively).


The most important goal in the prevention of primary stroke is that the risk factors leading to stroke are defined and changed.

Keywords: Acute ischemic stroke, acute phase reactants