ISSN 2149-5807 | E-ISSN 2149-6048
Original Article
Relationship between Heart-Type Fatty Acid-Binding Protein Levels and Severity and Extent of Coronary Atherosclerosis in Patients with Acute Myocardial Infarction
1 Department of Emergency Medicine, Ufuk University School of Medicine, Ankara, Turkey  
2 Department of Cardiology, Ufuk University School of Medicine, Ankara, Turkey  
3 Department of Medical Biochemistry, Ufuk University School of Medicine, Ankara, Turkey  
4 Department of Cardiology, VKV American Hospital, Istanbul, Turkey  
5 Department of Emergency Medicine, Bitlis State Hospital, Bitlis, Turkey  
Eurasian J Emerg Med ; : -
DOI: 10.5152/eajem.2018.62534
Key Words: Myocardial infarction, coronary artery disease, Gensini score, heart-type fatty acid-binding protein
Abstract

Aim: Heart-type fatty acid-binding protein (H-FABP) is an early marker of cardiac necrosis. It is rapidly released from the myocardium as a consequence of ischemic injury. We hypothesized that more severe and extensive coronary atherosclerosis results in more pronounced myocardial injury and necrosis in patients with acute myocardial infarction (AMI). Therefore, we aimed to analyze the relationship between serum H-FABP levels and the severity and extent of coronary artery disease (CAD) assessed using the Gensini score.


Materials and Methods
: Fifty patients with AMI who underwent invasive coronary angiography were divided according to their angiographic Gensini score into two groups, namely, the mild CAD group (Group 1) and the moderate-to-severe CAD group (Group 2). A point-of-care test and CardioDetect Quant device were used for detecting whether H-FABP was positive and for quantitative measurements. Data obtained from this study were evaluated using the PASW statistic program.


Results
: Mean serum H-FABP levels were significantly higher in Group 2 than in Group 1. Furthermore, a strongly positive correlation was found between the Gensini score and serum H-FABP levels.


Conclusions
: The findings of our study suggest that the amount of myocardial necrosis, demonstrated by serum H-FABP levels, is higher in patients with AMI with more severe and extensive CAD. H-FABP levels are also positively correlated with the Gensini score. We propose that H-FABP also provides a clue about the severity and extent of CAD, particularly in the setting of AMI.


Cite this article as
: Evrin T, Erkan AF, Ekici B, Demirtas S, Korkmaz S, Korkmaz A, et al. Relationship between Heart-type Fatty Acid-Binding Protein Levels and Severity and Extent of Coronary Atherosclerosis in Patients with Acute Myocardial Infarction. Eurasian J Emerg Med. DOI: 10.5152/eajem.2018.62534.

 

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